The emergence of Synthesis Intelligence (SI) has radically expanded the landscape of meaning and purpose, not just for technology, but for humanity itself. As we move into an era of close human–SI partnership, perennial existential questions—Why are we here? What does it mean to flourish?—demand to be revisited in this novel context.

Big Questions—queries addressing existence, truth, meaning, free will, and ethical responsibility—are foundational to existential inquiry, mentoring, and scientific progress.